CAS号: 34580-14-8

运用：用于荨麻疹、瘙痒症、湿疹、过敏性皮炎、特应性皮炎、神经性皮炎等过敏性疾病;近期报道治疗硬皮病有效，对支气管哮喘有很好的疗效，对过敏性哮喘疗效显著，混合型次之，感染型约半数有效，对哮喘有预防作用

副作用：The biggest side effect of ketotefen is somnolence or fatigue and weakness. This side effect is more obvious in adults and is one of the main reasons for the limitation of clinical use. The somnolence or fatigue can reduce the living quality of asthma and children's asthma. Usually, after 1-4 weeks of continuous administration, the side effects of central nerve suppression can be significantly reduced or even gradually disappeared. The clinical observation showed that the combination of theophylline and theophylline could reduce the central nervous inhibition of ketotefen, and counteract the central nerve excitability of theophylline, but the synergistic anti-inflammatory effect needed further observation. Clinical observations confirm that children usually do not have a significant central neurologic inhibitory effect on ketotefen, which can only cause inattention in children. Even if the dose is given to adults, the mechanism is not bbbbb. Wood and other clinical observations of two years of continuous oral administration of asthma and children's asthma confirmed that the long-term use of ketotefen did not have other serious side effects and had no effect on the liver, renal function and peripheral blood cell count, and it was not susceptible to resistance. Generally, after six weeks of continuous oral Administration of fumaric acid ketotefen, it could start to compete. Bronchial spasmodic or glucocorticoids were gradually reduced, and no rebound phenomenon was observed after long term treatment. Therefore, the comprehensive bbbbuation of the drug is that ketotefen is a kind of central nervous inhibition (the side effect can be adapted gradually), relatively safe and effective, with a certain anti inflammatory properties, low price antiasthmatic drugs. Since FDA has not been approved so far, it should be used cautiously in clinical practice.